In a standard PRP preparation, the platelet-poor plasma (PPP) is typically discarded — but it's rich in low-density extracellular vesicles, including exosomes, that transport proteins and microRNAs to support tissue regeneration, healing, and rejuvenation.
Standard PRP
✗Platelet-Poor Plasma → discarded
✓Platelet-Rich Plasma retained
✗Extracellular Fraction → not concentrated
SuperShot PRP® Aqueous Two-Phase System
✓PPP + SuperShot PRP® solution → 1-min spin
✓Extracellular Fraction → added to PRP
✓Zero waste
The Solution
Change the physics, not the protocol.
SuperShot PRP® uses a density gradient centrifugation solution to create an aqueous two-phase system that reduces the solubility of low-density lipoproteins — pelleting EVs at ordinary tabletop centrifuge speeds in just one minute. The result - a revolutionary EV rich PRP.
Fully Autologous
SuperShot PRP® concentrates what's already in the patient's blood — the same principle as concentrating platelets. Patient's own biology, zero foreign materials.
One Extra Minute
EVs can be pelleted at ordinary tabletop centrifuge speeds. The pelleted fraction is added back to your PRP. No new equipment required.
EV-Rich PRP
The result is PRP rich with Extracellular Vesicles — including exosomes — delivering the signaling molecules that can support regeneration.
By the Numbers
A measurable, reproducible enrichment.
Independent analysis via NanoSight particle tracking and Illumina single-end RNA sequencing.
845B
Extracellular Particles
Unique extracellular particles isolated from 5cc of plasma (169B/mL) with average 130nm diameter.
166×
More Than Allogeneic Exosomes
The leading allogeneic MSC exosome product contained just 0.6% of the EVs isolated by SuperShot PRP® from 5cc of plasma.
↑ miRNAs
microRNAs Enriched
Key signaling microRNAs that effect pathways of angiogenesis, cellular proliferation, and protein synthesis etc are captured.
Peer-Reviewed Research
The growing evidence for plasma exosomes.
Extracellular vesicles and the microRNAs they carry are an active frontier in regenerative medicine.
Muscle Regeneration
Exosomes from PRP and MSCs promote recovery of function after muscle injury
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FDA 510(k)
Cleared
Regulatory Status
SuperShot PRP® is an FDA 510(k) cleared device for the safe, rapid preparation of autologous platelet-rich plasma from a small sample of the patient's own blood.
Blood product per FDA guidance (July 2020, Section V.A)
Fully autologous — patient's own biology
Collected and delivered in a single surgical procedure
No allogeneic or xeno-sourced materials
For Patients
Your body has everything it needs to heal.
SuperShot PRP® is a one-minute advancement on standard PRP — concentrating your own platelets plus additional biomolecules normally discarded in a standard PRP procedure.
Every benefit of standard PRP — plus an additional fraction of extracellular messengers.
FDA 510(k) Cleared
SuperShot PRP® is an FDA 510(k) cleared device for preparing autologous PRP. No donor materials. No unknowns.
100% Your Own Biology
Everything in SuperShot PRP® comes from your own blood. No risk of allergic reaction, immune response, or transmissible disease.
Just One Extra Minute
SuperShot PRP® adds a single 1-minute spin to a standard PRP visit. Same appointment. More complete therapy.
What to Expect
Your SuperShot PRP®visit.
If you've had a standard PRP treatment before, your SuperShot PRP® experience will feel nearly identical — just more complete.
1
A simple blood draw
A small volume of blood is drawn from your arm — the same as a routine lab draw.
2
First spin
Your blood is spun to separate red blood cells from your whole plasma.
3
Second spin
Your whole plasma is spun to create a Platelet Rich Plasma (PRP) fraction that is set aside. The remaining Platelet Poor Plasma (PPP) is used for the next step.
✦
The SuperShot PRP® step
The PPP — normally discarded — is mixed with the centrifugation solution and spun for one additional minute. Your exosomes and other extracellular vesicles are isolated and added back to your PRP.
4
Your physician injects
Your complete SuperShot PRP® is injected into the treatment site by your physician.
Applications
Used across regenerative specialties.
Ask your provider whether SuperShot PRP® is appropriate for your condition.
Orthopedics & Joint Health
Sports Medicine
Aesthetics & Skin Rejuvenation
Hair Restoration
Sexual Wellness
Wound Healing
Frequently Asked Questions
What to know before your visit.
What are extracellular vesicles, and why do they matter?▼
Extracellular vesicles (EVs) are tiny membrane-enclosed particles released by cells. They carry proteins and microRNAs that act as signaling messengers — telling surrounding tissues how to repair, regenerate, and respond to injury. SuperShot PRP® concentrates these from your own plasma and adds them back to your PRP.
Is SuperShot PRP® safe?▼
Yes. SuperShot PRP® is FDA 510(k) cleared and uses only your own blood. Because it's fully autologous, there is no risk of allergic reaction, immune rejection, or transmissible disease.
Are PRP treatments painful?▼
Most patients experience mild discomfort at the injection site, comparable to a standard injection. Your provider may use topical numbing or other comfort measures depending on the treatment area.
How fast does PRP work?▼
Results vary by indication and individual. Some patients notice improvement within weeks; others see continued progress over 3–6 months as tissue remodels.
Is SuperShot PRP® autologous?▼
Yes — 100%. Everything in the SuperShot PRP® preparation comes from your own blood draw during the same appointment.
How is SuperShot PRP® different from "exosome injections" I've seen advertised?▼
Most marketed "exosome injections" use allogeneic (donor-derived) exosomes, which the FDA has flagged as unapproved biologics. SuperShot PRP® concentrates your own extracellular vesicles at point of care within a cleared PRP system — no donor materials, no regulatory gray area.
Is PRP covered by insurance?▼
PRP is generally not covered by insurance for most indications. Check with your provider's office for current pricing and any available financing options.
For Physicians
Why settle for standard PRP?
SuperShot PRP® is an FDA 510(k) cleared system that creates an EV-rich PRP at point of care. Add one minute to your workflow. Offer a fundamentally better biologic.
Everything you need to evaluate SuperShot PRP® for your practice — regulatory status, workflow impact, and clinical data at a glance.
Regulatory
FDA 510(k) Cleared
Source
100% Autologous
Added spin time
1 minute
Total processing
~10 minutes
Additional equipment
None
Training required
Minimal
EV particles isolated
~169B / mL plasma
Avg particle diameter
130nm (exosome range)
Clinical Case
The only PRP that concentrates platelets + an autologous EV fraction.
Standard PRP discards the platelet-poor plasma — and with it, hundreds of billions of low-density extracellular vesicles carrying the microRNAs that support regeneration. With SuperShot PRP® you can now create an EV rich PRP - the most complete.
845B
Particles / 5cc plasma
166×
More than top allogeneic exosome
130nm
Avg diameter · exosome range
2.4×
MSC growth vs. control (5-day)
Why SuperShot PRP® Fits Your Practice
A regulatory-clear, workflow-friendly upgrade.
FDA 510(k) Cleared
Cleared device for the preparation of autologous platelet-rich plasma from whole blood.
Aligned with FDA PRP Guidance
Blood product · autologous · same-procedure delivery · no processing beyond rinsing, cleansing, sizing, or shaping (July 2020 FDA guidance, §V.A).
No Donor Risk
No allogeneic or xeno-sourced materials. No risk from donor pathogens, unknown sourcing, unproven allogeneic biologics, or immuno-rejection.
One Additional Minute
Fits inside your existing PRP visit. A single additional 1-minute spin — no extra equipment, no protocol rewrite.
Differentiated Offering
The only EV-rich PRP process. Clear messaging, clear science, clear patient value — inside a regulatory-compliant biologic.
Outcomes Tracking
Provider outcomes tracking available through our registry partner — evidence-building at the point of care.
Swipe to view the full process →
Outcomes Registry
Track what matters.
Real-World Evidence
SuperShot PRP® is tracking outcomes for the most complete PRP. See first hand how the numbers measure up against standard PRP in a 2 year multi-center report for multiple cohorts.
